Regulation of the insulin-like growth factor 2 gene is central to the mechanisms used by cancer cells to sustain their proliferative and aggressive behavior. A new peer-reviewed article gives us an updated view of the underlying molecular mechanisms in a special issue of Biomedicines which we contributed as ISOPROG-Somatolink research…
We thank the editorial board of the “Cell Cycle” journal (*) for the publication of our review article entitled “Cell Cycle Control by the Insulin-like Growth Factor Signal: At the Crossroad between Cell Growth and Mitotic Regulation”. (*)https://www.tandfonline.com/…/10…/15384101.2022.2108117). Peer reviewers have defined it, respectively, “a remarkable piece of work” and…
The targetability of cancer secreted IGF-II and its self-stimulating loop with the insulin receptor in cancer has been exploited in our review article published on the journal “Cancers” [IF 6.162]
A novel cancer cell regulatory mechanism functionally linking the cancer cell secreted factor IGF-II and the self-stimulating signal leading to the steady over-expression of EphB4 in the same cells has been unfolded in the article published on the prestigious journal “Oncogene” (Nature Publishing Group) [Impact Factor 7.99]. The article discloses…