A novel cancer cell regulatory mechanism functionally linking the cancer cell secreted factor IGF-II and the self-stimulating signal leading to the steady over-expression of EphB4 in the same cells has been unfolded in the article published on the prestigious journal “Oncogene” (Nature Publishing Group) [Impact Factor 7.99]. The article discloses a number of previously unknown molecular details supporting the newly discovered rapid regulation of EphB4 by the IGF-II autocrine signal in cancer cells and its potential therapeutic targetability
