The ISOPROG-Somatolink EPFP Research Network gladly welcomes the publication of a peer-reviewed scientific review article on an emerging family of cellular enzymes with high biological value bringing unexpected novel insights on this class of cancer-promoting protein family. This article is fruit of our longstanding collaboration with the computational team of prof Carnevale at Temple’s College of Science and Technology and highlights the new member of this family which our team has recently discovered along with new findings on some other members of the same family of E3 ubiquitin ligases. The full paper can be downloaded at the following link: https://www.mdpi.com/2073-4409/12/13/1680