The relationship between receptors tyrosine kinases (RTKs) overexpression in cancer by growth-factors signaling and Degron domains has been addressed in the peer-reviewed article entitled: “Over-expression by degradation rescue of RTKs via cancer-secreted autocrine growth factors: a Phospho-degron-driven actionable layer of post-translational regulation?”
In this peer-reviewed perspective article authored by the ISOPROG-Somatolink EPFP Research Network and published on Frontiers of Oncology-Molecular and Cellular Oncology section, a novel role for the unexploited protein domains involved in phosphorylation/ubiquitin-regulated stability versus rapid degradation of proteins is proposed in the context of the expression of RTKs in physiology and cancer.
Link to the article https://www.frontiersin.org/…/fonc.2023.1278402/full…
