EphB4 is a blood vessel stimulatory factor over-expressed in human cancer cells but little has been known as for the factors regulating its gene expression. Such information can be derived in good part by the sequence and structure of each gene “promoter”region. In this work our team has reconstructed, sequenced and partially characterized the human EphB4 promoter region and discovered a different type of regulation compared to what had been previously described. This work allows scientists to further understand the molecular network affecting this developmentally and cancer-regulated gene
