Focusing on molecular mechanisms linking Obesity, Diabetes, and cancer in the special issue of Biomolecules. The full paper can be downloaded at the following URL:https://www.mdpi.com/…/special_issues/Insulin_IGF_Axis
Oncogenomics features of Melanoma play a key part in personalized cancer bio-profiling and treatment strategies. We have conveyed the scientific advances in our molecular understanding of this disease with specific focus on the intracellular abnormalities linked to target therapies and the role of the tumor microenvironment in this article published…
The targetability of cancer secreted IGF-II and its self-stimulating loop with the insulin receptor in cancer has been exploited in our review article published on the journal “Cancers” [IF 6.162]
EphB4 is a blood vessel stimulatory factor over-expressed in human cancer cells but little has been known as for the factors regulating its gene expression. Such information can be derived in good part by the sequence and structure of each gene “promoter”region. In this work our team has reconstructed, sequenced…
A novel cancer cell regulatory mechanism functionally linking the cancer cell secreted factor IGF-II and the self-stimulating signal leading to the steady over-expression of EphB4 in the same cells has been unfolded in the article published on the prestigious journal “Oncogene” (Nature Publishing Group) [Impact Factor 7.99]. The article discloses…